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All of you are familiar, no doubt, with the phagocytic theory of Metschnikoff, who, when his theory was first enunciated, believed that the white corpuscles which collect in such great numbers wherever pathogenic germs are gaining access to the system, are gathering for the purpose of warfare, and that they accomplish the destruction of the germs finally by a process viagra online asap of de- glutition! The definition of inflammation according to Metschnikoff 's theory is buy viagra wholesale a very simple thing; indeed, nothing more nor less than an encounter between the leucocytes or phagocytes on the one side and micro- 846 MEDICAL RECORD. [June 13, 1896 organisms on the other. The fiery red cheek of pneu- monia, the 106" F. temperature in typhoid fever, and the viagra online asap swollen and painful joint as a result of injury, are but evidences that a struggle for supremacy viagra online asap is going on in the system between the invaders from without and the defenders within. And, indeed, if one but watches from day to day the closing of an external wound, he will become al- most converted to this theory, for we do see unmistak- able evidences of strife. How they do repel the in- vaders which are clamoring to get in through the open wound by throwing up their breastworks within the gap! And should we fail to come to their assistance with our antiseptics, how very many of them die upon the ramparts, the dead bodies falling off in the shape of buy viagra wholesale pus corpuscles, showing how fearless and earnest is the struggle. viagra online asap That there is an increased number of white cor- puscles in and around the point where the body- is struggling against' disease or injury is a well- known fact, but just how the increase is brought about is not as yet fully understood. It is supposed to be due to a certain "psychical activity of their own," whereby the nucleolus becomes a nucleus, and the nucleus in turn is transformed into a leucocyte; or to a stimulus imparted to them by the nervous system, by which " they are swept out from the capillaries and tis- viagra online asap sues into the circulation," and then, I suppose, are transferred as a reinforcement to the parts most need- ing their assistance. The latter theory might explain their great increase after a cold bath, as first observed by Winternitz. But if we explain the raising of the arm for the defence of buy viagra wholesale the body in response to a nerve telegram, why can we not as readily understand that the influx of white corpuscles at a given point, also for defence, is in answer to a similar communication from the brain? This theory, defining the office of the white corpuscles to be that of the defenders of the sys- tem against animal and vegetable parasites, was a great stride in the right direction; but a greater one was the discovery of "nuclein" by Vaughan, demon- strating beyond a doubt that it is this substance (evidently a product of the leucocytes) which gives to the blood its germicidal power. Metschnikoff had already shown us how the vis medicatrix natures was brought into action, but it remained for Vaughan to reveal to us the long-hidden mystery what the vis medicatrix initio;,- really is. His discovery was to us as the brightness and warmth of the sun on a foggy morning, clearing the atmosphere of our minds from the accumulated mists of centuries. It seems there can be no doubt but that nuclein, proto-nuclein, spermin, antitoxin, or what- ever you choose to call it all being, I aver, one and the same substance whether secreted by the viagra online asap leuco- cytes or not, is at least carried by them to the locus lesionis, or point of attack, and there used as powder and ball against the invasion of poisonous germs : that when given as a medicine it increases the number of white corpuscles and stimulates as well their natural alertness and aggressiveness. Added to this, our knowledge that leucocytosis is the first physiological i iture takes in defence of the body buy viagra wholesale against patho- genic organisms c ertainly gives us reason to hope that the days of scientific treatment ol at least zymotic dis- eases is at hand. That a temporary leucocytosis is observed also dur- ing digestion would had to the supposition that the white blood-cells, owing buy viagra wholesale to their amoeboid pro ties, enabling them to traverse blood vessels and tissue without disturbing their integrity, are designed to per- form a double office, viz., as domestii laborers, iv the nutriment from the digestive tract to all parts viagra online asap of the body in such quantities as are needed for growth ami repair; and are, in a certain sense, warriors, in that they secrete or supply a germicidal substance called nuclein, which is antagonistic to, and protects the sys- tem against, the toxins emanating from poisonous bac- teria. In this connection you might ask, if leucocytosis is absolutely necessary for successful termination in the bodily struggles against disease, why is it that one does not speedily recover from that most obstinate of diseases, leucocytha:mia, seeing that the white cor- puscles are present in such superabundance? I shall try to answer by saying that a " leucocyte must be in full physiological activity before it can become a pha- gocyte'" ; that leucocythaemia should be looked upon only as a symptom of a systemic glandular disease, the buy viagra wholesale white corpuscles representing a once mighty army, but now, alas! only a straggling host of vanquished heroes being left with scarcely enough nucleinic strength for sluggish motion. They are here, in a word, mostly as dead or dying cells, incapable, in consequence, either of defensive action or of exercising their office as carriers of nutriment to the tissues the inevitable re- sult being general malnutrition, with pya-mia and ab- scesses in various buy viagra wholesale parts of the system. As Metschni- koff viagra online asap has abandoned his buy viagra wholesale "deglutition" theory, or so