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these animals to tuberculosis and the numerous sources from which they are liable to contract the disease, it would seem that serious error might occur by infec- tion before reaching the experimenter. It is quite probable that the majority sale viagra tescos of pigs come to the experi- menter already infected with tuberculous disease. The breeder or breeder's family might be affected with the disease and transmit it to the animals under their care. Former generations of animals might have been tuberculous and have transmitted to their offspring an abnormal susceptibility, besides disseminating conta- gion about the breeding-quarters. Outside of the sale viagra tescos question of accidental infection, either before or after the animal reaches the experimenter's hands, it would seem that no system whatever is observed to obtain a definite standard of animals. In view of the impor- tance oftentimes placed upon the results following the guinea-pig test, it would viagra tablet cutters seem that experimenters should unite with sale viagra tescos the object of securing an approxi- mate standard of general vitality in all animals uti- lized for experimental purposes. The obtaining of supplies from promiscuous sources is to be condemned as careless and unscientific. Either the State govern- ments should take steps to secure standard material for tests, or private enterprise should combine to se- viagra tablet cutters cure the same. In human beings we have practical every-day examples of the various elements which would contribute to render the present system of guinea-pig experimentation unreliable, and which demonstrate the necessity of securing a certain stan- dard of constitutional vitality in these animals. The sale viagra tescos same variation of susceptibility to tuberculosis which obtains in the human race must obtain from promiscu- ous breeding of guinea-pigs. The injection into one person of tuberculous infection such as is injected into the guinea-pig would not give rise to the disease, either locally at the point of injection, in remote sale viagra tescos parts of the body, or as a general infection, with any degree of uniformity. In some local disease would be produced, in others general tuberculosis, all dependent upon the influence of age, heredity, environment, food, exercise, etc. In a general way all the factors which enter into the determination of human susceptibility to tubercu- losis would obtain in tuberculosis of the lower ani- mals. The writer does not claim that all the various accidents which he has here mentioned are liable to present in each case, though there can be no doubt that more than one enter into all cases of experi- mental tuberculosis, and therefore he believes the re- sults following the common plan of injecting fluids into the bodies of guinea-pigs without regard to these various factors cannot be depended upon as decisive evidence as to the presence or absence of tuberculous infection. To summarize, these are the factors which singly or collectively may prevent accurate results : 1 st. Simultaneous infection from ordinary sources. 2d. The influence of general environment. 3d. Infection from contaminated quarters, either be- fore or after reaching the experimenter's care. 4th. The influence of food, bacteriologically and chemically. 5th. The influence of heredity. 6th. Direct infection from the breeder, the breeder's family, or the experimenter. FAILURE OF CASTRATION TO CAUSE ATROPHY OF THE PROSTATE. By CHARLES ];. KELSEY, M.D., PROFESSOR OF SURGERY AT THE NEW YORK POST-GRADUATE HOSPITAL. The patient, aged sixty-nine, came into the Post- Graduate Hospital suffering greatly with cystitis due to enlarged prostate. He had been unable to pass water for sale viagra tescos two or three months and had been catheter- ized by his wife every three or five hours. In addi- tion to a very large prostate he had right inguinal hernia and hydrocele on the left. The urine was al- buminous. Bassini's operation was done on the right side and both testicles were removed. After three weeks of careful catheterization and washing out of the bladder, there being very slight im- provement, if any, in his symptoms, a perineal section was made and permanent drainage established. Two weeks and a half later (five weeks and a half after castration) the patient died of chronic nephritis. As far as could be seen his death was not in any way hastened by the operative interference. viagra tablet cutters ImI lowing is the report of the pathologist to the hospital, Dr. Brooks: "New York, January 31, 1896. "My Dear Dr. Kelsey: The following is a brief report upon the prostate removed from castrated pa- tient : " Report. Mr. , aged sixty-nine. Prostate re- moved six hours after death. Weight : 45 sale viagra tescos grams. Dimensions: antero-posterior diameter, i|^ inches; transverse diameter (base), 2'_- inches; depth, 1 inch. "Gross Appearance. sale viagra tescos Color, dark red. Consist- ence firm, dense, moderately friable. The cut surface mottled and of a dark reddish-gray color; shows nu- merous delicate, silvery, grayish-white and grayish- red sale viagra tescos bands, united to form trabecular of greater or viagra tablet cutters less density and thickness, encircling prominent, irregu- larly outlined, nodulated foci which are pale yellow- viagra tablet cutters ish-white in color and of succulent consistence. These foci vary in size from that of a milletseed to that of a small pea. " Microscopical Examination In teased prepara- tions from the fresh organ, the elements composing the stroma, unstriated muscle, fibrous and elastic tis-