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in high doses for a long time without cumulative ef- fects. It stimulates the digestive functions and acts as a tonic, never causing vomiting or diarrhoea, as digitalis does. It slowed the pulse and the heart beats in tachycardia. It also cut short attacks of car- diac and bronchial asthma very rapidly. Its diuretic action was very marked. Still more recently Dr. Hochhalt, of Budapest, has published a number of cases favoring the therapeutic use of coronillin. He has noticed in cases of phthisis with continued fever, along with increase of arterial pressure and steadying of the heart's action, a certain lowering of tempera- ture. After summing up the work of previous ob- servers, viagra online bbc Professor viagra online bbc Prevost proceeds to give a detailed account of his own researches. For his experiments on frogs, Professor Prevost used two varieties, rana viagra pill substitute esculenta and rana temporaria. As with other heart poisons of the digitalis group, the latter shows itself more sensitive, and is poisoned with approximately half the dose. Frogs of the variety R. esculenta die with doses above viagra pill substitute 0.001 to 0.0015 gram per hundred grams body weight. For R. temporaria the dose is about half. The action on the heart is like that produced by digitalis. After a phase of " peristalsis" of the heart, which appears earlier or later according to the dose, the heart stops in systole of the ventricle and viagra online bbc diastole of the auricles, the auricles beating some time after the arrest of the viagra pill substitute ventricle. Bv means of Williams' apparatus, Professor Prevost obtained re- May 1 6, 1896] MEDICAL RECORD. 699 suits similar to those of Robert. The general symp- toms observed in the frog after poisoning by coronil- lin are like those produced by other heart poisons. The frog becomes weaker. The nerves and the mus- cles remain excitable for a certain time, but the exci- tability seems lost sooner than in a frog whose heart has been simply removed. When the dose has been insufficient to cause death of the heart, the frog often showed, even for several days, a general weakness with paralysis of the muscles. The nerves and the muscles are scarcely or not at all excitable, while the heart shows slow beats, arhythmic and peristaltic. Guinea- pigs show great sensitiveness to coronillin as to viagra pill substitute other heart poisons. The lethal dose is a little above 0.0002 gram per hundred grams body weight. Coro- nillin seems to be rapidly eliminated, and it is possible that it is not cumulative like digitalis. Diuresis was constant after the serious symptoms had improved, and the cardiac arhythmia had ceased. This is analogous to a phenomenon often observed with digitalis, when diuresis comes on only after the administration of the drug is suspended. White rats showed a great re- sistance to the effects of coronillin, as to all heart poi- sons. Even young rats have borne doses of 0.02 gram per hundred grains body weight. More or less diuresis occurs in all cases. The author was not able to ascer- tain the toxic dose, for he never reached it, nor has he observed in rats those curious nervous symptoms that he has noticed after the administration of large doses of digitalin. The difference in susceptibility of dif- ferent animals is a very interesting question, ft is observed with many poisons and is closely related to that of idiosyncrasy. The substances which vary in the relative dose per kilogram of animals are also those to which men show a different individual sus- ceptibility. Digitalin and the poisons of this group produce a notable rise of arterial pressure, which Traube considers the principal cause of the diuretic effects. Professor Prevost corroborates the observa- tions of MM. Schlagdenhauffen and Reeb that coronil- lin acts similarly in markedly raising the blood pres- sure. Summing up, the author gives a table of the toxic doses of coronillin administered hypodermi- cally for different animals. These doses are approxi- mately half those which he viagra pill substitute has viagra online bbc found for Homolle's digitalin, and correspond closely to those for Nati- velle's digitalin. Coronillin then, by hypodermic injection, proves to be a powerful heart poison. The clinical experiments of MM. Spillmann and Haushalter fix the effective dose viagra online bbc of coronillin administered by the mouth at from 0.20 to 0.30 gram and up to 0.60 gram per diem in divided doses. These doses seem large compared to the experimental toxic doses, prob- ably viagra pill substitute owing to viagra online bbc the difference in the method of admin- istration, the drug being much more powerfully toxic given hypodermically than by the mouth. Enlarged Bursas viagra pill substitute about the Knee. Dr. Roncali describes viagra pill substitute seven cases of enlarged bursa? about the knee, six of which were operated upon with complete success. One of the patients, a man aged twenty-five, fell on his left knee in January, 1893. Eight days after this the knee became swollen, and remained so for five months, then the swelling entirely disappeared. In Au- gust of the same year he noticed a swelling in the popli- teal space, which was rapidly increasing, causing a sense of viagra pill substitute weight and weakness in the limb but no pain or fever. The popliteal artery could be felt beating over the tumor; the swelling was seen to be divided into an upper section as large as an eight months' foetal head, and a lower one about the size of an orange. Pres- sure on the tumor caused no diminution in its size or alteration in the form of the joints. An incision was made over the tumor, and the bursa with three crypts firmly adherent to the posterior surface of the viagra online bbc capsule of the joint was removed. viagra online bbc There was no communica- tion with the joint. The patient was able to leave the hospital two months after, with perfect freedom of movement and completely cured. Archivo di Orto- padia. Some Practical Points in Connection with Rup- ture of the Female Perineum. Dr. Spanton states in the Provincial Medical Journal that he has operated on women of all ages between sixteen and seventv- three, and has found that age makes very little differ-